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KMID : 0377519890140030303
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Chung-Ang Journal of Medicine
1989 Volume.14 No. 3 p.303 ~ p.330
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The Development of Oxygen Toxicity in the Livers of Prednisone-Treated Rats, and Protective Effect of Liposomal Superoxide Dismutase
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Abstract
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We studied the changes of the activities of superoxide dismutase (EC 1.15.1.1, SOD), catalase (EC 1.11.1.6), peroxidase (EC 1.11.1.7) and xanthine oxidase (EC 1.1.3.22) in the livers of rats which were treated either with prednisone (10mg/IOOg body weight, group A) alone or with liposomal superoxide dismutase (3,000 units) followed by prednisone (10mg/1008 body weight,. group B).
The results were summarized as follows:
1. The activities of´Cu,Zri-SOD, Mn-SOD and catalase-in the group A were higher than those in the group B.
2. The activities of Cu,Zn-SOD and catalase in all experimental groups and `Mn-SOD in. group B decreased sequentially at 1,2,3,4 and 5 days through the experiments.
3. In all experimental groups, the peroxidase activities were higher than those in the controls, and the activities in the group A increased with time.
4. The activities of xanthine oxidase in the group A were higher than those in the group B.
From the above results, it appeared that prednisone administration could enhance the xanthine oxidase activity, and the production of oxygen radicals in rats´ liver, but the liposoinal SOD may effectively protect the liver from the oxygen toxicity. Accordingly, it could be suggested that prednisone induced oxygen toxicity in rat liver, and SOD, catalase and peroxidase, the scavengers of oxygen radicals, may. play an important role in defense mechanism of´ rat liver.
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